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发布时间:2021-12-03 15:40:56

1. Kim, H., Chen, J. * and Yu, X. * (2007). Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responses. Science, 316, 1202-1205. (* co-corresponding authors).

 

2. Liu, Z., Wu, J., and Yu, X. (2007). CCDC98 targets BRCA1 to DNA damage sites. Nature Structural and Molecular Biology, 14, 716-720.

 

3. Huen, M., Grant, R., Manke, I., Minn, K., Yu, X.*, Yaffe, M.* and Chen, J.* (2007). The E3 ubiquitin ligase RNF8 propagates the DNA damage signal via an ubiquitin-dependent signaling pathway. Cell, 131, 901-914. (*co-corresponding authors)

 

4. Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B. * and Yu, X. * (2009) PALB2 links BRCA1 and BRCA2 in the DNA damage response. Current Biology, 19: 524-529. (* co-corresponding authors) 

 

5. Lu, L.Y., Wu, J., Ye, L. Gavrilina, G.B., Saunders, T.L. and Yu, X. (2010). RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell. 18, 371-384.

 

6. Zhang, F. and Yu, X. (2011). WAC, a partner of RNF20/40 complex, regulates histone H2B ubiquitination and gene transcription. Molecular Cell. 41, 384-397.

 

7. Wu, J., Chen, Y., Lu, L.Y., Wu, Y., Paulsen, M.T., Ljungman, M., Ferguson, D.O. and Yu, X. (2011). Chfr and RNF8 synergistically regulate ATM activation. Nature Structural and Molecular Biology. 18: 761-768.

 

8. Chen, Q., Chen, Y., Bian, C., Fujiki, R. and Yu, X. (2013) TET2 promotes histone O-GlcNacylation during gene transcription. Nature 493:561-564.

 

9. Ma, T., Chen, Y., Zhang, F., Yang, C-Y., Wang, S. and Yu, X. (2013) RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Molecular Cell. 49: 897-907.

 

10. Li, M. and Yu, X. (2013) Function of BRCA1 in the DNA damage response is mediated by ADPribosylation. Cancer Cell. 23:693-704.

 

11. Lu, L, Korakavi, G., Kuang, H. and Yu, X. (2013) Distinct DNA damage responses on male meiotic sex Chromosomes. Nature Communications. 3015.

 

12. Li, M., Lu, L., Yang, C., Wang, S. and Yu, X. (2013) The FHA and BRCT domains recognize ADPribosylation during DNA damage response. Genes&Development. 27: 1752-1768.

 

13. Chen, Y., Chen, Q., McEachin, R.C., Cavalcoli J.D. and Yu, X. (2014) H2A.B facilitates transcription elongation at methylated CpG loci. Genome Research.24:570-579.

 

14. Zhang, F., Chen, Y., Li, M. and Yu, X. (2014) The OB-fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response. Proceedings of the National Academy of Sciences 111:7278-7283.

 

15. Li M, Chen Q, Ma T, and Yu X. (2017) Targeting reactive nitrogen species suppresses hereditary pancreatic cancer Proceedings of the National Academy of Sciences 114:7106-7111. 

 

16. Wang J, Yuan Z, Cui Y, Xie R, Wang M, Ma Y, Yu X* and Liu X.* (2018) Structure basis for the inhibition of the methyl-lysine binding function of 53BP1 by NUDT16L1/TIRR. (* co-corresponding authors) Nature Communications. 9:2689.

 

17. Chen Q, Kassab MA, Dantzer F and Yu X. (2018) PARP2 mediates branched poly-ADP-ribosylation in response to DNA damage. Nature Communications. 9: 3233.

 

18. Bian C, Zhang C, Vyas A, Chen S-H, Liu C, Luo T and Yu X. (2019) NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nature Communications.10:693.

 

19. Chen S-H and Yu X (2019) Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Science Advances. 5:eaav4340.

 

20. Singh AK, Zhao B, Wang X, Li H, Qin H, Wu X, Ma Y, Horne D and Yu X (2020) Selective targeting of TET catalytic domain promotes somatic cell reprogramming. Proceedings of the National Academy of Sciences 117:3621-3626.21.

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